Table 2 The results of the mediating effects identified in Mendelian randomization analysis.

From: Genetically predicted plasma metabolites mediate the causal relationship between gut microbiota and osteosarcoma

Exposure

Mediator

Outcome

Total effect

Mediation effect

P

Mediated proportion (%) (95% CI)

βAll (95% CI)

β12 (95% CI)

Phocea

Eugenol sulfate levels

Osteosarcoma

− 3.904 (− 5.828, − 1.980)

− 0.302 (− 0.553, − 0.0509)

0.018

7.74 (14.2, 1.3)

N-acetylphenylalanine levels

− 0.138 (− 0.241, − 0.0338)

0.009

3.52 (6.18, 0.867)

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