Fig. 1

Comparison of syngeneic tumor model mice intraperitoneally treated with anti-PD-1 antibodies. Schedule for inoculation of tumor cells (MC-38 or LLC1) and administration of anti-PD-1 mAb or isotype control to mice (A). Tumor growth in mice administered anti-PD-1 mAb or isotype control after the inoculation with LLC1 cells or MC-38 cells (each 1 × 106 cells/body, n = 5) is shown as the average values in panel (B) and as individual values in panel (C). The average body weight of mice administered anti-PD-1 mAb or isotype control after inoculation with LLC1 cells or MC-38 cells (each 1 × 106 cells/body) are shown in panel (D). Line graphs depict the average values with SEM (B) and SD (D).