Scientific Reports

Table 1 Correlation factors between tumor volumes and average ratios of lymphocytes expressing CD107a, granzyme B or perforin in tumors from LLC1 or MC-38 tumor-bearing mice intraperitoneally dosed with anti-PD-1 antibody.

From: Comprehensive immunophenotyping reveals distinct tumor microenvironment alterations in anti-PD-1 sensitive and resistant syngeneic mouse model

		LLC1/tumors			MC-38/tumors
		CD107a⁺	Granzyme B⁺	Perforin⁺	CD107a⁺	Granzyme B⁺	Perforin⁺
CD4⁺T cells	Isotype control	0.555	− 0.216	− 0.760	0.822	0.436	0.350
CD4⁺T cells	Anti-PD-1 mAb	0.075	− 0.457	0.590	0.473	− 0.975**	− 0.995**
CD8⁺T cells	Isotype control	0.431	− 0.199	− 0.936*	0.966**	0.193	0.502
CD8⁺T cells	Anti-PD-1 mAb	0.287	0.818	0.367	− 0.484	0.419	− 0.497
Tregs	Isotype control	0.768	0.829	− 0.326	0.778	0.583	0.758
Tregs	Anti-PD-1 mAb	− 0.554	− 0.798	0.788	0.887*	0.554	− 0.464
B cells	Isotype control	0.865	− 0.394	− 0.401	0.956*	− 0.104	− 0.202
B cells	Anti-PD-1 mAb	− 0.083	0.112	− 0.868	0.930*	0.315	− 0.405
NK cells	Isotype control	0.499	0.584	− 0.466	0.960**	0.954*	0.394
NK cells	Anti-PD-1 mAb	0.499	− 0.135	− 0.409	0.703	− 0.486	− 0.003
NKT cells	Isotype control	0.552	− 0.016	− 0.451	0.962**	0.511	0.664
NKT cells	Anti-PD-1 mAb	− 0.500	− 0.462	0.254	0.770	− 0.224	− 0.934*

Correlation factor: r, *P < 0.05, **P < 0.01.

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