Table 2 Baseline lesion characteristics and quantitative angiographic parameter pre- and post-procedure, and at angiographic follow-up.

From: Predictors of optimal angiographic lesion outcomes in drug-coated balloon treatment for de novo coronary artery disease

 

All lesions

(n = 451)

SR lesion

(n = 93)

Non-SR lesion

(n = 358)

p value

Target lesion location

0.968

 LAD/Diagonal (%)

142/47 (41.9%)

32/4 (38.7)

110/43 (42.7)

 

 LCX/OM (%)

114/25 (30.8%)

29/4 (35.5)

85/21 (29.6)

 

 RCA/PDA or PLV (%)

99/30 (23.7)

20/2 (23.7)

79/28 (23.7)

 

 Ramus intermedius (%)

16 (3.5%)

2 (2.2)

14 (3.9)

 

ACC/AHA lesion type

0.416

 Type A (%)

30 (6.7)

7 (7.5)

23 (6.4)

 

 Type B1 (%)

84 (18.6)

16 (17.2)

68 (19.0)

 

 Type B2 (%)

162 (35.9)

40 (43.0)

122 (34.1)

 

 Type C (%)

175 (38.8)

30 (32.3)

145 (40.5)

 

 Type B2 or C (%)

337 (74.7)

70 (75.3)

267 (74.6)

0.892

Lesion morphology

0.042

 Concentric

141

28 (30.1%)

113 (31.6%)

 

 Eccentric

208

52 (55.9%)

156 (43.6%)

 

 Multiple irregularities

102

13 (14.0%)

89 (24.9%)

 

Angiographic calcification

0.048

 No/mild calcifications (%)

255 (56.5%)

63 (67.7)

192 (53.6)

 

 Moderate calcification (%)

148 (32.8%)

22 (23.7)

126 (35.2)

 

 Severe calcification (%)

48 (10.6)

8 (8.6)

40 (11.2)

 

QCA (pre-procedure)

 Lesion length (mm)

19.81 ± 6.60

18.88 ± 6.70

20.05 ± 6.56

0.129

 Lesion RVD (mm)

2.53 ± 0.47

2.66 ± 0.48

2.49 ± 0.47

0.001

 Lesion MLD (mm)

0.75 ± 0.37

0.77 ± 0.40

0.75 ± 0.36

0.583

 Lesion DS (%)

70.20 ± 13.59

71.11 ± 14.40

69.96 ± 13.39

0.466

DCB treatment procedure

 Specialty balloon used* (%)

201 (44.6)

51 (54.8)

150 (41.9)

0.025

 Max balloon diameter (mm)

2.96 ± 0.50

3.19 ± 0.52

2.90 ± 0.48

< 0.001

 Balloon-to-artery ratio

1.102 ± 0.109

1.129 ± 0.107

1.095 ± 0.109

0.008

 Dissection (%)

157 (34.8)

26 (28.0)

131 (36.6)

0.119

QCA (post-DCB treatment)

 Lesion RVD (mm)

2.70 ± 0.46

2.84 ± 0.47

2.66 ± 0.45

0.001

 Lesion MLD (mm)

1.89 ± 0.46

2.14 ± 0.47

1.83 ± 0.44

< 0.001

 Lesion DS (%)

29.99 ± 10.71

24.70 ± 10.06

31.36 ± 10.46

< 0.001

 Acute luminal gain (mm)

1.14 ± 0.50

1.37 ± 0.50

1.08 ± 0.49

< 0.001

QCA (Follow-up angiogram)

 Lesion RVD (mm)

2.63 ± 0.47

2.77 ± 0.45

2.60 ± 0.47

0.002

 Lesion MLD (mm)

1.85 ± 0.53

2.37 ± 0.38

1.72 ± 0.48

< 0.001

 Lesion DS (%)

30.50 ± 13.89

14.68 ± 3.87

34.61 ± 12.54

< 0.001

 Late lumen loss (mm)

0.04 ± 0.41

-0.21 ± 0.32

0.11 ± 0.41

< 0.001

 Net lumen gain

1.10 ± 0.56

1.60 ± 0.48

0.97 ± 0.50

< 0.001

 Binary restenosis

28 (6.2%)

0 (0.0%)

28 (7.9%)

0.003

  1. Data are expressed as frequency (percent) or mean ± standard deviation.
  2. *Specialty balloons includes both scoring (96.5%) and non-compliant (3.5%) balloons.
  3. ACC/AHA, American College of Cardiology/American Heart Association; DS, diameter stenosis; LAD, left anterior descending; LCX, left circumflex; MLD, minimal lumen diameter; OM, obtuse marginal; SR, optimal result; PDA, posterior descending artery; PLV, posterior left ventricular; QCA, quantitative coronary angiography; RCA, right coronary artery; RVD, reference vessel diameter.
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