Fig. 1 | Scientific Reports

Fig. 1

From: BRPF1 inhibition reduces migration and invasion of metastatic ovarian cancer cells, representing a potential therapeutic target

Fig. 1

Identification of candidate targets for metastatic ovarian cancer treatment. (A) Overview of CRISPR-Cas9 loss-of-function genetic screens analysis. The flow diagram depicts the criteria used for the selection of 75 genes with elevated essentiality in metastatic OC cells. (B) Histogram depicting the mean chronos score in primary (SP) and metastatic (SM) tumor-derived cell lines and the difference between the two (Δ(SM-SP)) for the top 20 genes characterized by maximum difference between the two values. (C) A network of 14 proteins involved in epigenetic regulation of gene expression determined by STRING protein-protein network interaction analysis.

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