Fig. 2 | Scientific Reports

Fig. 2

From: BRPF1 inhibition reduces migration and invasion of metastatic ovarian cancer cells, representing a potential therapeutic target

Fig. 2

BRPF1 expression and prognostic significance in OC. Dot plots showing BRPF1 mRNA expression in (A) ovarian tumors, stroma, and normal ovarian surface epithelium; OC tumors of different stages (B) and grade (C) in the CSIOVDB database. (D) Dot plot showing BRPF1 expression in Clear Cell, Endometrioid, Mucinous, Mucinous-LMP, Serous, and Serous-LMP OC tumors. (* p < 0.05) (E) Kaplan-Meier curves showing overall survival of OC patients relative to BRPF1 mRNA expression (low expression values below the first quartile, high expression: values above the third quartile). (F) Histogram showing BRPF1 protein expression in 15 OC cell lines obtained by MS analysis by Coscia, F. et al.20. (G) BRPF1 protein expression in available OC cell lines determined by WB. β-Actin was used as loading control for immunoblot (Upper panel). Whole blots are shown in Supplementary Fig. S1, while two additional biological replicates are reported in Supplementary Fig. S2. Relative densities of the bands were normalized to ß-Actin from the same gel. Results are presented as the mean ± standard deviation of three biological replicates (Lower panel).

Back to article page