Table 3 Structural and functional effects of NsSNPs predicted by MutPred2.
Substitution position | MutPred2 score | Effect |
|---|---|---|
D390Y | 0.753 | Altered Ordered interface; Loss of Relative solvent accessibility; Altered Metal binding; Altered Transmembrane protein; Loss of Disulfide linkage at C388; Loss of Sulfation at Y393 |
Y262C | 0.733 | Altered Ordered interface; Altered Transmembrane protein; Altered Metal binding; Gain of Disulfide linkage at Y262; Loss of Proteolytic cleavage at D265; Loss of Sulfation at Y262 |
P180L | 0.778 | Altered Ordered interface; Altered Metal binding; Altered Transmembrane protein; Loss of Relative solvent accessibility; Loss of Catalytic site at H175; Gain of Proteolytic cleavage at D182; Gain of Sulfation at Y179 |
C329S | 0.858 | Loss of Disulfide linkage at C329; Gain of Relative solvent accessibility; Altered Metal binding; Altered Ordered interface; Altered Transmembrane protein |
M422R | 0.649 | Altered Transmembrane protein; Altered Ordered interface; Altered Disordered interface; Gain of Strand; Loss of Relative solvent accessibility; Loss of Sulfation at Y420 |
G183E | 0.908 | Altered Transmembrane protein; Loss of Relative solvent accessibility; Altered Metal binding; Loss of Methylation at K184; Gain of Sulfation at Y179 |
D434N | 0.687 | Altered Disordered interface; Altered Transmembrane protein; Altered Metal binding; Loss of Ubiquitylation at K433 |
G306C | 0.836 | Altered Metal binding; Altered Ordered interface; Altered Transmembrane protein; Gain of Disulfide linkage at C302 |
G438A | 0.656 | Altered Metal binding; Gain of Ubiquitylation at K433; Altered Transmembrane protein |
C347Y | 0.912 | Altered Transmembrane protein; Altered Metal binding; Loss of Disulfide linkage at C347 |
R98L | 0.884 | Altered Ordered interface; Altered Transmembrane protein; Altered DNA binding; Gain of Catalytic site at C99; Gain of Proteolytic cleavage at D103; Loss of Disulfide linkage at C99 |
