Table 4 Stability predictions of NsSNPs using iSTABLE, MuPro, I-Mutant-2, dynamut, and duet.
Amino Acid Substitution | iSTABLE | MuPro | I-Mutant 2 | Dynamut | Duet | |||||
|---|---|---|---|---|---|---|---|---|---|---|
Stability | Score | Stability | Score | Stability | RI | Stability | ∆∆G mCSM | Stability | ∆∆G | |
D390Y | Decrease | 0.66 | Decrease | 0.447 | Decrease | 1 | Stabilizing | 0.136 | Stabilizing | 0.249 |
Y262C | Decrease | 0.55 | Decrease | -1 | Decrease | 4 | Destabilizing | -1.757 | Destabilizing | -1.773 |
P180L | Increase | 0.60 | Increase | 0.632 | Decrease | 6 | Destabilizing | -0.675 | Destabilizing | -0.026 |
C329S | Decrease | 0.52 | Decrease | -0.773 | Decrease | 7 | Destabilizing | -1.036 | Destabilizing | -0.886 |
M422R | Decrease | 0.79 | Decrease | -0.600 | Decrease | 3 | Destabilizing | -1.047 | Destabilizing | -0.79 |
G183E | Decrease | 0.70 | Decrease | -0.946 | Decrease | 1 | Destabilizing | -1.933 | Destabilizing | -2.162 |
R98L | Increase | 0.71 | Increase | 0.038 | Decrease | 8 | Destabilizing | -0.574 | Destabilizing | -0.286 |
D434N | Decrease | 0.62 | Decrease | -0.902 | Decrease | 7 | Destabilizing | -0.546 | Destabilizing | -0.35 |
G306C | Decrease | 0.69 | Decrease | -0.559 | Decrease | 8 | Destabilizing | -0.807 | Destabilizing | -1.052 |
G438A | Decrease | 0.74 | Decrease | -0.107 | Decrease | 4 | Destabilizing | -0.621 | Stabilizing | 0.032 |
C347Y | Decrease | 0.64 | Decrease | -0.219 | Decrease | 2 | Destabilizing | -1.118 | Stabilizing | -1.087 |
