Table 1 Antimicrobial susceptibility profile to beta-lactam antibiotics for an S. maltophilia strain deficient in smlt1522 and an E. coli strain heterologously expressing smlt1522.

From: An acyl-homoserine lactone acylase found in Stenotrophomonas maltophilia exhibits both quorum quenching activity and the ability to degrade penicillin antibiotics

Beta-lactam antibiotic

Minimum inhibitory concentration (MIC)a

S. maltophilia K279a

S. maltophilia K279a Δsmlt1522

S. maltophilia K279a Δsmlt1522/ pBBR1-BAD-smlt1522

E. coli DH5a / pBBR1-BAD

E. coli DH5a / pBBR1-BAD-smlt1522

Carbapenems

Imipenem

128

128

128

0.25

0.25

Meropenem

32

32

64

0.0625

0.0625

Cephalosporins

Ceftazidime

8

8

8

0.0625

0.0625

Penicillins

Ampicillin

128

128

256

2

8

Piperacillin

64

32

64

0.5

2

Piperacillin-tazobactam

16

16

16

0.5

0.5

Ticarcillin

32

32

64

2

4

Ticarcillin-clavulanic

2

2

2

2

2

  1. aMinimum inhibitory concentration (MIC) determined by the broth microdilution method. The MIC is expressed in µg/mL. MICs were confirmed by four independent replicates and MIC differences greater than 2-fold with respect to each corresponding control strain were considered significant (indicated in bold).
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