Table 2 LS-means (95% CIs) of plasma inflammatory markers according to the quartiles of SFA intake.

From: Intakes of saturated and unsaturated fat and circulating levels of inflammatory markers among breast cancer survivors

LS-means (95% CIs)

Quartiles of SFA intake, g/da

p for trend

Q1

Q2

Q3

Q4

No. of participants

104

105

106

104

 

Inflammatory composite score

 Age-adjusted

0.31 (-0.23, 0.86)

-0.19 (-0.73, 0.35)

-0.01 (-0.55, 0.54)

-0.09 (-0.64, 0.46)

0.409

 MV-adjusted

0.52 (-0.29, 1.32)

0.27 (-0.51, 1.04)

0.48 (-0.33, 1.30)

0.34 (-0.47, 1.15)

0.788

 MV + BMI adjusted

0.49 (-0.28, 1.26)

0.19 (-0.54, 0.92)

0.58 (-0.20, 1.35)

0.24 (-0.53, 1.01)

0.712

Adiponectin (µg/mL)

  Age-adjusted

9.64 (8.50, 10.92)

9.14 (8.07, 10.35)

9.87 (8.71, 11.16)

9.91 (8.73, 11.23)

0.591

 MV-adjusted

9.34 (7.73, 11.24)

8.46 (7.05, 10.12)

9.19 (7.60, 11.07)

9.45 (7.82, 11.39)

0.693

 MV + BMI adjusted

9.38 (7.82, 11.21)

8.59 (7.21, 10.21)

9.01 (7.50, 10.78)

9.64 (8.04, 11.53)

0.628

hs-CRP (mg/L)

 Age-adjusted

0.68 (0.56, 0.82)

0.53 (0.42, 0.66)

0.63 (0.51, 0.76)

0.60 (0.48, 0.73)

0.630

 MV-adjusted

0.82 (0.62, 1.04)

0.67 (0.50, 0.87)

0.72 (0.53, 0.93)

0.71 (0.52, 0.92)

0.383

 MV + BMI adjusted

0.81 (0.62, 1.03)

0.66 (0.49, 0.84)

0.74 (0.55, 0.95)

0.69 (0.51, 0.89)

0.339

IL-6 (pg/mL)

 Age-adjusted

0.95 (0.84, 1.07)

0.85 (0.75, 0.96)

0.91 (0.81, 1.03)

0.96 (0.85, 1.08)

0.673

 MV-adjusted

0.97 (0.80, 1.15)

0.89 (0.73, 1.05)

0.94 (0.78, 1.12)

1.01 (0.84, 1.20)

0.493

 MV + BMI adjusted

0.97 (0.80, 1.15)

0.88 (0.73, 1.05)

0.95 (0.78, 1.13)

1.00 (0.84, 1.19)

0.511

IL-8 (pg/mL)

 Age-adjusted

11.87 (10.18, 13.90)

11.11 (9.56, 12.96)

10.32 (8.88, 12.01)

10.69 (9.18, 12.49)

0.291

 MV-adjusted

10.81 (8.66, 13.58)

10.57 (8.56, 13.14)

10.34 (8.30, 12.98)

10.56 (8.46, 13.26)

0.812

 MV + BMI adjusted

10.78 (8.66, 13.52)

10.47 (8.49, 12.98)

10.48 (8.42, 13.13)

10.43 (8.38, 13.07)

0.780

TNF-α (pg/mL)

 Age-adjusted

12.11 (10.88, 13.40)

11.52 (10.33, 12.76)

12.26 (11.04, 13.54)

11.23 (10.03, 12.48)

0.463

 MV-adjusted

12.29 (10.54, 14.18)

12.12 (10.45, 13.91)

13.52 (11.67, 15.48)

11.98 (10.24, 13.84)

0.999

 MV + BMI adjusted

12.29 (10.53, 14.17)

12.09 (10.42, 13.87)

13.56 (11.72, 15.53)

11.93 (10.20, 13.80)

0.988

  1. BMI, body mass index; CI, confidence interval; hs-CRP, high-sensitivity C-reactive protein; IL, interleukin; LS-means, least-squares means; MV, multivariate; SFA, saturated fat; and TNF, tumor necrosis factor.
  2. aSFA intake values were adjusted for total energy intake using the residual method.
  3. Age-adjusted: adjusted for age at consent (years, continuous).
  4. MV-adjusted: adjusted for age at consent (years, continuous), center, physical activity (MET-hours/week, quartiles), total energy intake (log-transformed, kcal/day, continuous), education level (middle school or below, high school, and college or above), alcohol drinking status (non-drinkers, current drinkers), smoking status (never smokers, ever smokers), menopausal status at diagnosis (premenopausal, postmenopausal), dietary supplement use (no, yes), AJCC stage at diagnosis (I, II, and III), time since surgery (0.5 to < 2 years, 2 to < 5 years, and ≥ 5 years), radiotherapy use (no, yes), hormonal therapy use (no, yes), and history of chronic disease (no, yes).
  5. MV + BMI adjusted: additionally adjusted for BMI (log-transformed, kg/m², continuous).
  6. A few participants did not have information on some inflammatory markers: n = 4 for inflammatory composite score, n = 3 for adiponectin, IL-6, IL-8, and TNF-α, and n = 1 for hs-CRP.
Back to article page