Fig. 5 | Scientific Reports

Fig. 5

From: MYBL2 promotes cell proliferation and inhibits cell apoptosis via PI3K/AKT and BCL2/BAX/Cleaved-caspase-3 signaling pathway in gastric cancer cells

Fig. 5

MYBL2 activates the PI3K/AKT signaling pathway in GC cells. (A) The p-PI3K, p-AKT and AKT protein expression were examined by Western blot after transfecting siRNA targeting MYBL2 for 48 h in HGC27 cells. (B) Western blot analysis of the expression of p-PI3K, p-AKT and AKT proteins after transfecting AGS cells for 48 h with MYBL2 overexpression vector. (C) Effect of the AKT inhibitor MK2206 on MYBL2-induced cell. (D) MYBL2 contributes to GC cell growth and inhibits cell apoptosis by regulating PI3K/AKT and BCL2/BAX/Cleaved-caspase-3 signaling pathways in GC cells. *P < 0.05, **P < 0.01, ***P < 0.001 vs. NC.

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