Table 1 Comparative analysis of clinical parameters.

From: Elevated serum CD40 as a potential biomarker for the differential diagnosis of acute thyrotoxic myopathy

Clinical parameters

ATM

(N = 17)

GD

(N = 17)

Control

(N = 17)

ATM vs. GD

χ2/t/z value

ATM vs. GD

P value

ATM vs. control

χ2/t/z value

ATM vs. control

P value

GD vs. control

χ2/t/z value

GD vs. control

P value

Female

14

13

13

0.64

1.00

0.64

1.00

0.64

1.00

BMI

19.74 ± 1.66

20.61 ± 1.50

20.52 ± 1.20

-1.60

0.12

-1.58

0.12

0.18

0.86

Age (years)

37.29 ± 13.26

39.12 ± 12.59

39.82 ± 10.20

-0.41

0.68

-0.62

0.54

-0.18

0.86

CD40 (pg/ml)

259.17(227.50,378.03)

190.71 (174.08,198.96)

166.98(142.94,175.90)

-4.87

< 0.01

-4.98

< 0.01

-3.93

< 0.01

FT3 (pmol/L)

28.34(17.13,37.65)

8.82(6.36,21.00)

5.02(3.93,5.45)

-2.93

< 0.01

-4.97

< 0.01

-3.70

< 0.01

FT4 (pmol/L)

67.58(37.53,77.23)

27.03(15.96,47.05)

16.82(13.59,17.90)

-2.89

< 0.01

-4.85

< 0.01

-2.46

0.01

TSH (mIU/L)

0.01(0.01,0.01)

0.01(0.01,0.01,0.21)

1.90(1.43,2.43)

-1.29

0.32

-5.16

< 0.01

-4.01

< 0.01

TGAb (%)

31.20(7.38,54.47)

17.67(10.61,46.49)

8.44(7.61,10.59)

-0.36

0.73

-2.15

0.03

-3.36

< 0.01

TRAb (IU/L)

16.90(5.64,40.00)

8.55(1.64,17.20)

0.25(0.25,0.25)

-1.82

0.07

-5.03

< 0.01

-4.40

< 0.01

TPOAb (IU/ml)

727.00(265.75, 986.00)

587.00(132.00,1000.00)

0.57(0.47,1.08)

-0.33

0.76

-4.95

< 0.01

-4.81

< 0.01

K (mmol/L)

4.13 ± 0.43

4.22 ± 0.42

4.30 ± 0.35

-0.57

0.57

-1.24

0.23

-0.62

0.54

ATMSS

8.76 ± 5.11

1 ± 1.12

-

6.13

< 0.01

-

-

-

-

  1. ATM: Acute Thyrotoxic Myopathy; GD: Graves’ disease. FT3: Free Triiodothyronine; FT4: Free Thyroxine; TSH: Thyroid-Stimulating Hormone; TGAb: Thyroglobulin Antibodies; TRAb: Thyroid Receptor Antibodies; TPOAb: Thyroid Peroxidase Antibody; K: Serum Potassium; ATMSS: Acute Thyrotoxic Myopathy Symptom Score. Normally distributed continuous data are presented as mean ± standard deviation, and intergroup comparisons are made using independent samples T-tests. Non-normally distributed continuous data are expressed as median M(P25, P75), and comparisons between groups are performed using the Mann-Whitney U test, with P < 0.05 indicating statistically significant differences.