Table 4 Sensitivity analyses of adjusted HRs and 95% CIs for risk of specific-site cancer across the trajectories of life’s essential 8 scores in Kailuan study.

From: The association of life’s essential 8 scores trajectory patterns with the risk of all cancer types

 

LE8 scores trajectory patterns

P for trend

Low-stable

Moderate-stable

Elevated-stable

Exclude participants who took antihypertensive drugs (n = 43,509)

Overall cancer

Ref.

0.86 (0.77, 0.96)

0.78 (0.68, 0.89)

0.001

Lung cancer

Ref.

0.90 (0.73, 1.11)

0.74 (0.57, 0.96)

0.069

Breast cancera

Ref.

0.47 (0.30, 0.74)

0.48 (0.30, 0.77)

0.003

Colorectal cancer

Ref.

0.75 (0.57, 1.00)

0.64 (0.45, 0.92)

0.016

Liver cancerb

Ref.

0.75 (0.50, 1.14)

0.68 (0.42, 1.12)

0.271

Exclude participants who took hypoglycemic drugs (n = 47,282)

Overall cancer

Ref.

0.86 (0.77, 0.95)

0.79 (0.70, 0.90)

0.001

Lung cancer

Ref.

0.85 (0.70, 1.04)

0.72 (0.56, 0.92)

0.032

Breast cancera

Ref.

0.48 (0.32, 0.73)

0.48 (0.30, 0.75)

0.001

Colorectal cancer

Ref.

0.85 (0.64, 1.13)

0.73 (0.52, 1.00)

0.181

Liver cancerb

Ref.

0.64 (0.44, 0.93)

0.62 (0.39, 0.98)

0.041

Exclude participants who took lipid-lowering drug drugs (n = 47,869)

Overall cancer

Ref.

0.85 (0.77, 0.95)

0.79 (0.70, 0.90)

0.001

Lung cancer

Ref.

0.85 (0.70, 1.04)

0.72 (0.57, 0.92)

0.029

Breast cancera

Ref.

0.50 (0.34, 0.75)

0.48 (0.31, 0.74)

0.001

Colorectal cancer

Ref.

0.81 (0.62, 1.06)

0.70 (0.50, 0.98)

0.099

Liver cancerb

Ref.

0.68 (0.47, 0.98)

0.60 (0.38, 0.95)

0.052

Exclude participants with cancer diagnosed within 1st year of follow-up (n = 48,066)

Overall cancer

Ref.

0.82 (0.74, 0.92)

0.76 (0.66, 0.86)

< 0.001

Lung cancer

Ref.

0.84 (0.68, 1.03)

0.64 (0.50, 0.83)

0.003

Breast cancera

Ref.

0.52 (0.33, 0.84)

0.51 (0.33, 0.79)

0.003

Colorectal cancer

Ref.

0.79 (0.60, 1.05)

0.67 (0.47, 0.95)

0.073

Liver cancerb

Ref.

0.69 (0.47, 1.02)

0.65 (0.41, 1.05)

0.120

  1. Adjusted models include age, gender, WC, CRP, drinking status, marital status, family income, and sedentary lifestyles.
  2. Results presented with bold valued were statistically significant with all p value < 0.05.
  3. a: Conducted only in women.
  4. b: Further adjusted for HBV infection, liver cirrhosis and fatty liver disease.
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