Table 1 Baseline characteristics.

From: Cardiopulmonary exercise capacity markers and their link to symptom burden in patients at risk for heart failure with non-reduced ejection fraction

 

Total Cohort

NYHA I CPET

NYHA II CPET

NYHA I vs. II CPET (p-value)

NYHA I KCCQ

NYHA II KCCQ

NYHA I vs. II KCCQ (p-value)

Men

Women

Men vs. women (p-value)

n

62

32

30

n.s.

36

24

 

34

28

n.s.

Men/women (n)

34/28

19/13

15/15

n.s.

21/15

12/12

n.s.

34

28

< 0.001

Hypertension (n)

46

24

22

n.s.

29

17

n.s.

   

Coronary heart disease (n)

21

10

11

n.s.

14

6

n.s.

15

6

n.s.

Diabetes mellitus II (n)

8

3

5

n.s.

4

4

n.s.

4

4

n.s.

Beta-blocker yes/no (n)

33/29

16/16

17/13

n.s.

24/12

9/13

n.s.

20

13

n.s.

Age (y)

68.40 (8.10)

65.81 (9.32)

71.17 (5.45)

= 0.004

68.47 (7.83)

67.75 (8.73)

n.s.

70.00 (6.02)

66.46 (9.83)

= 0.044

Height (cm)

172.7 (8.0)

173.4 (7.3)

171.9 (8.7)

n.s.

172.2 (7.9)

173.2 (8.5)

n.s.

177.9 (5.5)

166.4 (5.5)

< 0.001

Weight (kg)

76.10 (9.60)

75.44 (10.01)

76.80 (9.27)

n.s.

77.2 (9.3)

73.8 (10.1)

n.s.

81.32 (8.03)

69.75 (7.31)

< 0.001

Body mass index (kg/m2)

25.48 (2.31)

25.03 (2.47)

25.96 (2.05)

n.s.

26.2 (2.12)

24.5 (2.3)

= 0.003

25.70 (2.10)

25.22 (2.55)

n.s.

Fat free mass (kg)

55.46 (9.88)

56.03 (9.25)

54.83 (10.66)

n.s.

56.34 (10.32)

54.13 (9.46)

n.s.

62.73 (6.53)

46.31 (3.88)

< 0.001

Body fat (%)

27.36 (7.26)

25.78 (6.43)

29.10 (7.82)

= 0.038

27.89 (7.38)

26.61 (7.32)

n.s.

22.67 (4.86)

33.26 (5.18)

< 0.001

NTproBNP (ng/l)

242.7 (176.0)

220.8 (159.3)

266.1 (192.1)

n.s.

213.6 (99.8)

286.6 (250.6)

n.s.

259.4 (216.4)

222.4 (109.4)

n.s.

Ejection fraction (%)

59.16 (5.60)

58.94 (5.10)

59.40 (6.16)

n.s.

57.92 (5.40)

61.21 (5.62)

= 0.013

57.82 (5.12)

60.79 (5.81)

= 0.019

Heart rate (bpm)

69.21 (10.46)

70.25 (10.58)

68.10 (10.40)

n.s.

68.47 (8.49)

69.29 (12.729

n.s.

68.91 (10.4)

69.57 (10.75)

n.s.

SBP (mmHg)

143.10 (16.09)

140.80 (15.94)

145.70 (16.12)

n.s.

144.60 (15.85)

140 − 50 (16.43)

n.s.

145.10 (16.28)

140.70 (15.80)

n.s.

DBP (mmHg)

82.84 (8.29)

83.00 (8.04)

82.67 (8.69)

n.s.

83.83 (8.46)

81.79 (8.24)

n.s.

82.59 (9.22)

83.14 (7.16)

n.s.

Cardiac output (l/min)

7.09 (1.12)

7.07 (1.34)

7.12 (1.04)

n.s.

7.04 (1.20)

7.09 (1.15)

n.s.

7.245 (1.38)

6.91 (0.92)

n.s.

Stroke Volume (ml)

103.50 (17.68)

101.30 (18.11)

106.00 (17.19)

n.s.

103.50 (18.14)

104.0 (17.8)

n.s.

106.10 (18.94)

100.5 (15.83)

n.s.

FVC (l)

3.62 (0.86)

3.76 (0.74)

3.45 (0.96)

n.s.

3.61 (0.85)

3.55 (0.88)

n.s.

4.12 (0.71)

2.98 (0.55)

< 0.001

FEV1/FVC (%)

78.0 (7.62)

79.3 (7.21)

76.6 (7.93)

n.s.

77.94 (5.86)

77.92 (9.93)

n.s.

78.80 (8.80)

74.23 (15.80)

n.s.

FEF 75 − 25% (l)

2.59 (1.10)

2.84 (1.06)

2.31 (1.09)

0.028

2.56 (1.06)

2.56 (1.15)

n.s.

3.05 (1.08)

2.00 (0.76)

< 0.001

KCCQ summary score

78.3 (15.33)

79.63 (15.61)

76.78 (15.14)

n.s.

88.52 (6.93)

62.97 (10.989

< 0.001

78.25 (15.25)

78.4 (15.7)

n.s.

KCCQ symptoms score

80.2 (18.6)

80.67 (18.9)

79.72 (18.6)

n.s.

92.36 (6.98)

62.02 (15.35)

< 0.001

80.40 (18.61)

80.01 (18.92)

n.s.

KCCQ functional score

81.4 (15.3)

82.57 (15.26)

80.02 (15.5)

n.s.

91.37 (6.02)

65.85 (11.25)

< 0.001

81.85 (15.58)

80.81 (15.25)

n.s.

KCCQ clinical score

80.1 (15.8)

81.38 (16.18)

78.7 (15.6)

n.s.

90.57 (6.75)

64.47 (12.08)

< 0.001

79.95 (15.62)

80.36 (16.35)

n.s.

  1. Entries are mean and standard deviation. Abbreviations: DBP: diastolic blood pressure, FEF: forced expiration flow, FVC: forced vital capacity, KCCQ: Kansas City Cardiac Questionnaire, NTproBNP: N-terminal pro–B-type natriuretic peptide, NYHA: New York Heart Association; SBP: systolic blood pressure.
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