Table 2 Time-dependent Cox regression analysis of mortality risk factors in patients with severe fever with thrombocytopenia syndrome.

From: Dynamic biomarkers and Cox regression with time-dependent covariate for mortality prediction in severe fever with thrombocytopenia syndrome

Variable

Univariate cox regression

Multivariate cox regression

Hazards ratio (95% CI)

p-value

Hazards ratio (95% CI)

p-value

WBC count

1.181 (1.115, 1.251)

< 0.001

  

Platelet count

0.987 (0.978, 0.996)

0.006

  

Neutrophil count

1.066 (1.036, 1.098)

< 0.001

1.063 (1.017, 1.112)

0.007

Lymphocyte count

0.959 (0.637, 1.445)

0.839

  

Monocyte count

0.351 (0.086, 1.431)

0.142

  

Hemoglobin

0.890 (0.768, 1.031)

0.118

  

Hematocrit

0.971 (0.934, 1.01)

0.141

  

Sodium

1.072 (1.009, 1.138)

0.025

  

Potassium

2.454 (1.867, 3.225)

< 0.001

  

AST

1.001 (0.985, 1.017)

0.950

  

ALT

1.002 (1.001, 1.002)

< 0.001

  

LDH

1.000 (1.000, 1.000)

< 0.001

1.000 (1.000, 1.000)

< 0.001

Total Bilirubin

1.790 (1.513, 2.118)

< 0.001

1.311 (1.111, 1.546)

0.002

Total Protein

0.359 (0.165, 0.783)

0.011

  

Albumin

0.107 (0.063, 0.184)

< 0.001

0.469 (0.263, 0.835)

0.011

BUN

1.042 (1.033, 1.050)

< 0.001

1.031 (1.023, 1.040)

< 0.001

Creatinine

2.186 (1.751, 2.729)

< 0.001

  

CRP

1.012 (1.006, 1.018)

< 0.001

  

Troponin-I

1.069 (1.037, 1.102)

< 0.001

  

CK-MB

1.160 (1.095, 1.230)

< 0.001

  

PT

1.036 (1.029, 1.042)

< 0.001

1.146 (1.080, 1.215)

< 0.001

aPTT

1.016 (1.012, 1.020)

< 0.001

1.014 (1.004, 1.025)

0.008

pH

1.173 (0.805, 1.709)

0.400

  

PaCO2

1.011 (0.959, 1.067)

0.674

  

PaO2

1.013 (1.009, 1.018)

< 0.001

  
  1. Abbreviations: SFTS, Severe fever with thrombocytopenia syndrome; CI, confidence interval; AST, Aspartate aminotransferase; ALT, alanine aminotransferase; LDH, lactate dehydrogenase; BUN, blood urea nitrogen; CRP, C-reactive protein; CK-MB, creatine phosphokinase MB fraction; PT, prothrombin time; aPTT, activated partial thromboplastin time; eGFR, estimated glomerular filtration rate.
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