Table 3 Univariate analysis of PFS and OS in 214 patients with PCNSL.

From: Antiepileptic drugs failed to prevent initial seizures or improve survival outcomes in patients with primary CNS lymphoma

Clinical characteristics

Median PFS

HR

95% CI

χ2

P value

Median OS

HR

95% CI

χ2

P value

Seizures

 Yes

4.1

1.692

(1.138–2.517)

6.979

0.009

27.5

1.700

(0.986–2.929)

3.648

0.053

 No

12.6

   

46.0

   

EEG

 Abnormal

6.9

2.041

(1.124–3.705)

5.774

0.016

30.4

2.463

(0.939–6.462)

3.357

0.058

 Normal

22.0

   

39.9

   

ECOG

 ≥ 2

4.9

2.035

(1.460–2.835)

18.465

0.000

27.5

2.924

(1.770–4.829)

17.564

0.000

 < 2

18.0

   

56.6

   

LDH level

 Elevated

5.9

1.101

(0.707–1.715)

0.183

0.669

27.5

2.031

(1.162–3.553)

6.175

0.012

 Normal

10.5

   

56.6

   

Focality

 Multiple lesions

4.9

1.459

(1.060–2.008)

5.492

0.021

43.6

1.311

(0.827–2.079)

1.324

0.248

 Solitary lesion

13.1

   

43.6

   

Response to HD-MTX

 CR/PR

24.8

0.042

(0.025–0.071)

216.326

0.000

54.1

0.285

(0.172–0.472)

23.828

0.000

 SD/PD

2.5

   

23.7

   

AEDs

 Applied

5.2

1.398

(1.010–1.935)

4.340

0.039

43.6

1.342

(0.837–2.152)

1.490

0.220

 Not-applied

15.9

   

46.0

   

Deep involvement

 Yes

6.9

1.773

(1.158–2.716)

7.197

0.007

39.9

1.831

(0.977–3.430)

3.568

0.055

 No

18.0

   

56.6

   

Volume of lesion

 Diameter ≥ 3 cm

5.3

1.514

(1.085–2.112)

6.104

0.012

51.3

0.855

(0.530–1.381)

0.409

0.522

 Diameter < 3 cm

15.8

   

39.9

   
  1. EEG: electroencephalogram; ECOG, Eastern Cooperative Oncology Group; HD-MTX, high dose- methotrexate; LDH: lactate dehydrogenase; CR: complete response; PR: partial response; SD: stable disease; PD: progressive disease; AEDs: antiepileptic drugs.
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