Fig. 2 | Scientific Reports

Fig. 2

From: Genetic effects of circulating hormone and proteome on amyotrophic lateral sclerosis identified by Mendelian randomization

Fig. 2

Mendelian randomization association of genetically predicted growth and sex hormones with ALS. Odds ratios are scaled per genetically predicted standard deviation change in IGF-1, inverse-normal transformed nmol/L change in FT and TT, natural log transformed nmol/L change in SHBG, and pmol/L change in estradiol. ALS, amyotrophic lateral sclerosis; FT, free testosterone; IVW, the inverse-variance weighted method; IGF-1, insulin-like growth factor 1; MR, Mendelian randomization; OR, odds ratio; SHBG, sex hormone-binding globulin; TT, total testosterone.

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