Fig. 3 | Scientific Reports

Fig. 3

From: Aquaporin 9 downregulation in KRASG12V colorectal cancer and associated with increased proliferation and decreased apoptosis in cancer cells

Fig. 3

AQP9 overexpression reduces proliferation and boosts apoptosis, while its knockdown increases proliferation and reduces apoptosis in KRASG12V CRC cells. (A) Schematic representation of the construction of the AQP9 overexpression plasmid. (B, C) Protein quantification of AQP9 following overexpression in KRASG12V CRC cells. (B) Western blot, (C) Quantitative results. (D) Proliferation levels of KRASG12V CRC cell following AQP9 overexpression. (E) Apoptosis levels of KRASG12V CRC cell following AQP9 overexpression. (F, G) AQP9 knockdown protein levels in KRASG12V CRC cells (F Western blot, G Quantitative analysis). (H) KRASG12V CRC cell proliferation post-AQP9 knockdown. (I) KRASG12V CRC cell apoptosis post-AQP9 knockdown.

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