Table 2 Correlation between AQP9 expression and clinicopathological parameters of colorectal cancer.

From: Aquaporin 9 downregulation in KRASG12V colorectal cancer and associated with increased proliferation and decreased apoptosis in cancer cells

Clinical and Pathological index

AQP9 Expression

P

Low

Medium

High

Age

< 65

8

29

5

0.003*

≥ 65

17

24

24

 

Gender

Male

15

30

19

0.773

Female

10

23

10

 

Metastasis

Yes

4

3

3

0.360

No

20

46

24

 

Node positive

Yes

15

25

13

0.671

No

9

19

13

 

TNM

I-II

9

25

13

0.422

III-IV

16

23

14

 

PD-L1

Positive

4

7

2

0.251

Negative

7

6

8

 

Macroscopic types

Ulcerative

8

16

13

0.323

Infiltrative

16

32

13

 

Tumor location

Left-sided colon and rectum

19

34

19

0.565

Right-sided colon

6

19

10

 

Tumor maximum diameter

≤ 4 (cm)

9

31

20

0.033*

> 4 (cm)

16

23

8

 

MMR

Proficient

24

50

28

0.886

Deficiency

1

3

1

 

Histological classification

Tubular adenocarcinoma

17

39

23

0.360

Mucinous adenocarcinoma

1

6

1

 

Differentiation

Well

3

2

6

 

Moderate

16

34

18

0.071

Poor

4

15

13

 

KRAS

G12V

9

2

0

0.001*

WT

9

23

21

 

OTHER

7

28

8

 
  1. *Indicates statistically significant difference.
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