Table 2 Association between absolute and average cumulative dose and all-cause mortality risk.

From: Differential association between cumulative dose of 5α-reductase inhibitors and mortality

Variables

Control (n = 14630)

Case (n = 3084)a

All-cause mortality

p-for-trend

All-cause mortality

p-for-trend

n

(%)

n

(%)

Crude HR

95% CI

aHRb

95% CI

5-alpha reductase inhibitor

              

Never user (less than 30 cDDDs)

6695

(45.8)

1225

(39.7)

1.000

    

1.000

    

Ever user

7935

(54.2)

1859

(60.3)

1.294

1.190

-

1.407

 

1.169

1.049

-

1.302

 

Cumulative dose

        

0.1995

    

0.0507

Less than 365 cDDDs

2699

(34.0)

760

(40.9)

1.544

1.390

-

1.715

1.346

1.177

-

1.539

365 ~ 730 cDDDs

1038

(13.1)

263

(14.1)

1.387

1.190

-

1.616

1.258

1.040

-

1.522

730 ~ 1460 cDDDs

1130

(14.2)

271

(14.6)

1.311

1.127

-

1.526

1.133

0.935

-

1.372

1460 ~ 2920 cDDDs

1144

(14.4)

251

(13.5)

1.195

1.022

-

1.395

1.111

0.913

-

1.352

2920 ~ 5840 cDDDs

896

(11.3)

178

(9.6)

1.070

0.894

-

1.281

0.912

0.730

-

1.139

More than 5840 cDDDs

1028

(13.0)

136

(7.3)

0.708

0.580

-

0.863

0.732

0.577

-

0.930

Cumulative dose

        

0.3268

    

0.7126

Q1 (Less than 200 cDDDs)

1891

(23.8)

524

(28.2)

1.519

1.349

-

1.711

1.267

1.090

-

1.473

Q2 (200 ~ 751.5 cDDDs)

1965

(24.8)

517

(27.8)

1.447

1.285

-

1.629

1.338

1.151

-

1.556

Q3 (751.5 ~ 2566 cDDDs)

1976

(24.9)

471

(25.3)

1.307

1.155

-

1.478

1.169

0.998

-

1.369

Q4 (more than 2566 cDDDs)

2103

(26.5)

347

(18.7)

0.887

0.774

-

1.017

0.828

0.697

-

0.984

Average cumulative dose per year

        

0.7272

    

0.2226

Less than 30 cDDDs/year

1537

(19.4)

418

(22.5)

1.544

1.353

-

1.762

1.287

1.091

-

1.517

30 ~ 180 cDDDs/year

2609

(32.9)

692

(37.2)

1.475

1.323

-

1.643

1.279

1.115

-

1.467

180 ~ 365 cDDDs/year

1255

(15.8)

295

(15.9)

1.314

1.135

-

1.521

1.306

1.084

-

1.574

365 ~ 730 cDDDs/year

1006

(12.7)

226

(12.2)

1.249

1.062

-

1.469

1.019

0.828

-

1.254

730 ~ 1460 cDDDs/year

906

(11.4)

169

(9.1)

1.035

0.864

-

1.240

0.931

0.740

-

1.170

More than 1460 cDDDs/year

622

(7.8)

59

(3.2)

0.493

0.371

-

0.655

0.524

0.374

-

0.736

Average cumulative dose per year

        

0.1534

    

0.9659

Q1 (Less than 40.5 cDDDs/year)

1926

(24.3)

522

(28.1)

1.519

1.344

-

1.716

1.288

1.105

-

1.501

Q2 (40.5 ~ 148.5 cDDDs/year)

1924

(24.2)

525

(28.2)

1.516

1.346

-

1.708

1.328

1.142

-

1.543

Q3 (148.5 ~ 488.4 cDDDs/year)

2007

(25.3)

441

(23.7)

1.214

1.071

-

1.375

1.100

0.938

-

1.290

Q4 (more than 488.4 cDDDs/year)

2078

(26.2)

371

(20.0)

0.983

0.862

-

1.120

0.911

0.769

-

1.079

  1. The text in bold font indicates a statistically significant difference.
  2. Abbreviations: aHR, adjusted hazard ratio; CI, confidence interval; cDDD, cumulative defined daily dose.
  3. a Patients who died were classified as cases.
  4. b Adjusted for Area of residence, Economic status, Insurance type, Physical activity, Alcohol status, Smoking status, Body mass index, Number of outpatient visits per year, Number of admission, Alpha blocker, Prostate surgical intervention, Comorbidity.
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