Table 2 The consistency of RT-PCR and pathological examination in detecting aberrant methylation of the SEPTIN9, SDC2, and BCAT1 gene.
PCR (SEPTIN9 + SDC2 + BCAT1) | Pathological examination | Total | |
|---|---|---|---|
Positive | Negative | ||
Positive | 90 | 11 | 101 |
Negative | 14 | 233 | 247 |
Total | 104 | 244 | 348 |
AUC | 0.929 | ||
95%CI | 0.897–0.954 | ||
Kappa | 0.827 | ||
Sensitivity | 86.1% | ||
Specificity | 97.6% | ||
Positive predictive value (PPV) | 57.2% (CRC incidence rate of 0.0359% [18]) | ||
Negative predictive value (NPV) | 99.5% (CRC incidence rate of 0.0359% [18]) | ||
