Table 4 Subtype analysis. Stage and histology-specific performance of the SEPTIN9, SDC2, and BCAT1 methylation biomarkers using plasma samples from patients with suspected colorectal.
Stage | Histology | Ļ2 test (P value) | |||
|---|---|---|---|---|---|
Colon | Rectum | Others | Total | ||
Tumor stage | 0.60131 | ||||
Ā Tx | 7/7 (100%) | 10/11 (90.9%) | 1/1 (100%) | 18/19 (94.7%) | |
Ā T0 | ā | 3/3 (100%) | ā | 3/3 (100%) | |
Ā T1 | 2/2 (100%) | 1/2 (50.0%) | ā | 3/4 (75.0%) | |
Ā T2 | 4/7 (57.1%) | 7/7 (100%) | ā | 11/14 (78.6%) | |
Ā T3 | 23/25 (92.0%) | 20/26 (76.9%) | 2/2 (100%) | 45/53 (84.9%) | |
Ā T4 | 6/6 (100%) | 3/4 (75.0%) | ā | 9/10 (90.0%) | |
Ā Unknown | ā | 1/1 (100%) | ā | 1/1 (100%) | |
Ā Total | 42/47 (89.4%) | 45/54 (83.3%) | 3/3 (100%) | 90/104 (86.5%) | |
Node stage | Ā | ||||
Ā Nx | 8/8 (100%) | 11/13 (84.6%) | 1/1 (100%) | 20/22 (90.9%) | 0.70296 |
Ā N0 | 23/27 (85.2%) | 18/22 (81.8%) | 1/1 (100%) | 42/50 (84.0%) | |
Ā N1 | 6/6 (100%) | 11/14 (78.6%) | 1/1 (100%) | 18/21 (85.7%) | |
Ā N2 | 5/6 (83.3%) | 4/4 (100%) | ā | 9/10 (90.0%) | |
Ā Unknown | ā | 1/1 (100%) | ā | 1/1 (100%) | |
Ā Total | 42/47 (89.4%) | 45/54 (83.3%) | 3/3 (100%) | 90/104 (86.5%) | |
Metastasis stage | Ā | ||||
Ā Mx | ā | 1/1 (100%) | ā | 1/1 (100%) | 0.46938 |
Ā M0 | 26/31 (83.9%) | 27/32 (84.4%) | 1/1 (100%) | 54/64 (84.4%) | |
Ā M1 | 16/16 (100%) | 16/20 (80.0%) | 2/2 (100%) | 34/38 (89.5%) | |
Ā Unknown | ā | 1/1 (100%) | ā | 1/1 (100%) | |
Ā Total | 42/47 (89.4%) | 45/54 (83.3%) | 3/3 (100%) | 90/104 (86.5%) | |
TNM stage | Ā | ||||
Ā I | 5/8 (62.5%) | 7/8 (87.5%) | ā | 12/16 (75.0%) | 0.90839 |
Ā II | 16/17 (94.1%) | 8/10 (80.0%) | 1/1 (100%) | 25/28 (89.3%) | |
Ā III | 5/6 (83.3%) | 8/10 (100%) | ā | 13/16 (81.3%) | |
Ā IV | 15/15 (100%) | 17/21 (81.0%) | 2/2 (100%) | 34/38 (89.5%) | |
Ā Unknown | 1/1 (100%) | 5/5 (100%) | ā | 6/6 (100%) | |
Ā Total | 42/47 (89.4%) | 45/54 (83.3%) | 3/3 (100%) | 90/104 (86.5%) | |
