Fig. 3 | Scientific Reports

Fig. 3

From: Polygenic score analysis identifies distinct genetic risk profiles in Alzheimer’s disease comorbidities

Fig. 3

Association of comorbidity-PGSs with AD onset in individuals from the UK biobank: (A) Shows are the OR and the 95% confidence interval for AD comorbidities in the AD subset, 60–70 (Green), 70–80 (Red) and > 80 (Purple) age at onset. OR was obtained with a logistic regression for comorbidity using age, sex and the first four PC as covariates comparing 20% of high PGS with the rest of the group in each age interval. (B,C) Comparison of AD onset in a subset of AD patients with High AD-PGS in groups with high and low (B) EPI-PGS and (T2D-PGS). The mean comparison was assessed with the T student test.

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