Fig. 10

Importance of IL-17 signaling in Indomethacin-induced gastric injury. (a): GO enrichment analysis on the differentially expressed genes of neutrophils in control group and model group; (b): Bubble plot of GO enrichment; (c): Bar plot of Reactome enrichment; (d): Bubble plot of Reactome enrichment; (e): Bar plot of KEGG enrichment; (f): Bubble plot of KEGG enrichment; (g): Neutrophil IL-17 signaling expressions in the mucosal layer (×40, scale bar = 20 µm), red indicates IL-17R, green indicates MPO, and blue indicates DAPI-stained nucleus; (h): Proportions with positive expression of MPO in the mucosal layer, bar: mean ± SE, n = 4; (i): Proportions with positive expression of IL-17R, bar: mean ± SE, n = 4; (j): Proportions with co-expression of MPO and IL-17R in the mucosal layer, bar: mean ± SE, n = 4; (k): IL-17 concentration, bar: mean ± SE, n = 4, vs control group, ^**P < 0.01, ^*P < 0.05.