Fig. 4

Integrating different transcriptomic analyses demonstrates differences between COVID-19 severities. Venn diagram for genes identified as DEGs (p-value < 0.01 and baseMean > 10), AS (p-value < 0.01) and APA (p-value < 0.01) in (a) severe vs. moderate and (b) critical vs. moderate. The genes in common from all analysis (middle of Venn) are shown in a table next to the Venn diagram. Made with ggvenn (v0.1.10) and ggtexttable (ggpubr v0.6.0) in R (v4.2.1). Venn diagram of pathways affected by DEGs, AS genes and APA genes in (c) severe vs. moderate and (d) critical vs. moderate. Made with ggvenn (v0.1.10). (e) Pathways identified with DEGs, AS and APA in common in severe vs. moderate and critical vs. moderate. The dot represents the severe vs. moderate group, the triangle represents the critical vs. moderate group, the size represents the Fold Enrichment of the pathway, the color scale represents the -log10(FDR), with a higher value (lighter color) meaning a more significant pathway (lower FDR). The x axis represents the Gene ratio (number of genes dysregulated divided by total number of genes implicated in the pathway), and the y axis are the pathways. Made with ggplot2 (v3.4.3) in R (v4.2.1). All panels were assembled with cowplot (1.1.1) in R (v4.2.1).