Fig. 4

(a) Current transient peak shape for an oblate shaped protein (IgG) that can translocate through a nanopore in two extreme orientations, either with its major axis orthogonal to the direction of flow (1) or parallel to the flow direction (2). (b) RPS current trace for a spherically shaped protein (streptavidin) as a function of translocation time through the in-plane nanopore. Also shown is the anticipated current transient event, which adopts a square-type shape. (c) Different orientational directions for proteins translocating through the in-plane pore.