Fig. 5 | Scientific Reports

Fig. 5

From: Glucosamine induces hepatic FGF21 expression by activating the Akt/mTOR/p70S6K axis and driving PGC-1α activity

Fig. 5

GlcN infusion increased plasma levels and hepatic expression of FGF21, as well as lipogenesis-related genes in mice. C57BL/6J mice were infused with GlcN or saline for 2 weeks. (a, b) FGF21 levels in plasma and liver were measured. (c) Hepatic expression of FASN was assessed (n = 6). (d) AML12 cells were co-treated with OA and GlcN for 24 h, followed by quantification of Oil Red O staining (n = 3). Scale bar: 100 μm. Data are presented as mean ± SEM. *P < 0.05 compared with control.

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