Fig. 5 | Scientific Reports

Fig. 5

From: Baseline abundance of Akkermansia muciniphila and Bacteroides acidifaciens in a healthy state predicts inflammation associated tumorigenesis in the AOM/DSS mouse model

Fig. 5

Correlation between the identified “marker” features in the microbiotas of two mouse colonies at two experimental time points: before AOM injection (the “Before” time point) and after three rounds of DSS (the “cDSS” time point). (A) Correlation heatmap representing the Spearman correlation (ρ > 0.5) between the abundances of the identified markers at the “Before” and “cDSS” time points. Correlations that are not significant are crossed out. Correlations with Benjaminni-Hochberg adjusted p-value < 0.05 are marked significant. (B–E) Abundances of selected marker features at the “Before” and “cDSS” time points (n = 8−13). * p < 0.05, ** - p < 0.01, *** p < 0.001 by the Wilcoxon test with Benjaminni-Hochberg correction (f14f4_Akkermansia_muciniphila: Before_R1 vs. Before_R2 W = 95, p = 0.002; Before_R2 vs. cDSS_R2 W = 2, p = 0.002; 80130_Bacteroides_acidifaciens: Before_R1 vs. Before_R2 W = 96, p = 0.003; c5aa3_Desulfovibrio_fairfieldensis: Before_R1 vs. cDSS_R1 W = 4, p = 0.00016; Before_R2 vs. cDSS_R2 W = 8, p = 0.014; cDSS_R1 vs. cDSS_R2 W = 100, p = 0.00023; Lachnospiraceae_NK4A136_group: cDSS_R1 vs. cDSS_R2 W = 2, p = 0.001). Value points shown in red indicate outliers. (F–H) The Spearman correlation between selected features and tumor burden in mice with developed tumors. Correlations and Benjaminni-Hochberg adjusted p-value are presented in pictures.

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