Fig. 3 | Scientific Reports

Fig. 3

From: Development and validation of a novel endoplasmic reticulum stress-related lncRNA signature in laryngeal squamous cell carcinoma

Fig. 3

Construction of an ERS-related lncRNA Prognostic signature and analysis of independent prognostic potentials. (A) The forest plot showing the results of univariate Cox regression analysis of 35 prognostic ERS-related lncRNAs; (B) The heatmap showing the expression levels of these 35 genes in LSCC and normal tissues; (C) Cross-validation in LASSO regression to optimize parameter selection; (D) LASSO coefficient profile; (E–H) PCA illustrates that the model lncRNA group (H) is most effective in differentiating patients in high and low risk groups than ERS-related lncRNAs (E), ERS-related genes (F) and all genes (G); (I-J) Univariate and multivariate analysis assessing relationship between risk scores and relevant clinical parameters and OS in the TCGA–LSCC cohort; (K) The Nomogram model of the risk score and clinical indicators for predicting 1-year, 3-year, and 5-year OS of LSCC patients; (L) Calibration curves of the nomogram prediction of OS of patients in TCGA-LSCC cohort.

Back to article page