Table 2 Summary of overlapping differentially expressed genes in trabecular bone (identified in the present study) and in subchondral bone (identified by Duan et al.13) from the femoral head of ONFH patients.
Differentially expressed genes in the FH vs. IT of ONFH patients and in the study by Duan et al. | |
|---|---|
Upregulated | GGH,GRN,GYG1,NARF,PIM1,SNTB1,UBE2O |
Downregulated | ADGRF5,ALDH1L1,APOD,BLID,CD34,CDH5,CFH,COL4A1,CORO6,DLL4,EBF2,ECSCR,FILIP1L,FMO2,FRZB,GIPC2,HOXB7,KCNK3,KITLG,LAMA3,LAMB1,MRAP,MYL9,NDRG2,PDGFA,PLCXD3,RUNDC3B,TINAGL1,ZFPM2 |
Different direction of regulation | ABCA8,AIF1,ANKRD13A,ANKRD29,ANXA3,APOBR,AQP1,ARHGAP30,ART4,BST1,C1QB,CAMP,CAV1,CCL18,CD82,CDC6,CHI3L1,CLEC3B,CLMP,COL15A1,COL1A1,CSTA,DIAPH3,DUSP5,EGR2,FBXO16,FCN1,FGF2,GAPT,GSPT1,HBEGF,HMBS,HTRA1,IL6R,JAM3,LCP1,LGALS12,LNX1,LRP4,LRRC15,LTF,MALL,MKX,MNAT1,MNDA,MYO1G,NUF2,OR4Q3,ORM1,P2RX1,PADI4,PAG1,PAMR1,PLA2G7,PLAT,PLXNC1,POLE,PRRG4,RARRES1,RHOG,RNASET2,S100A12,S100A9,S100P,SERPINF1,SLC7A2,SORL1,SPP1,SULF1,TARM1,TFDP2,TMEM150B,WWC2,ZBTB7B |
Differentially expressed genes in the FH between ONFH and OA patients and in the study by Duan et al. | |
Upregulated | TK2,LCTL,GRN |
Downregulated | PADI4,KIF3A,JAKMIP3,HYOU1 |
Different direction of regulation | TMEM176B,TMEM150B,TFPT,PCDH17,HLA-DRA,FAM20A,DZIP1L,CTSH,CD163,CCL19,CCL18,C1QB |
