Table 3 Multivariate analysis of factors associated with macular retinal layer thickness in eyes with primary open-angle glaucoma (149 eyes of 117 patients).

From: Relationships between distance from the fovea to the disc and macular retinal layer thickness differ between normal and glaucomatous eyes

Variables

Macular RNFL

GCIPL

Outer retina

Coeff. [SE]

P value

Coeff. [SE]

P value

Coeff. [SE]

P value

FDD (mm)

– 2.31 [0.99]

0.019

– 4.26 [1.32]

0.0013*

– 5.30 [2.13]

0.013

Age (year)

0.03 [0.03]

0.34

– 0.04 [0.04]

0.33

– 0.22 [0.09]

0.009

Sex (Male)

0.67 [0.63]

0.29

1.79 [0.85]

0.04

4.59 [1.74]

0.008

MD (dB)

0.09 [0.08]

0.31

0.27 [0.11]

0.019

0.04 [0.14]

0.79

Axial length (mm)

– 0.12 [0.32]

0.70

– 0.20 [0.43]

0.64

0.66 [0.81]

0.41

Corneal radius (mm)

0.29 [1.22]

0.81

1.93 [1.64]

0.24

– 2.81 [3.07]

0.36

Intraocular pressure (mmHg)

0.07 [0.12]

0.54

0.16 [0.16]

0.31

– 0.05 [0.27]

0.86

Disc area (mm2)

– 1.81 [0.61]

0.0031*

– 1.53 [0.81]

0.06

2.09 [1.22]

0.09

Ovality index

3.53 [2.28]

0.12

– 1.21 [3.01]

0.69

– 0.62 [4.32]

0.89

Torsion angle (degree)

0.002 [0.008]

0.78

0.03 [0.01]

0.006

– 0.008 [0.01]

0.53

FDA (degree)

– 0.08 [0.07]

0.25

– 0.12 [0.09]

0.16

0.01 [0.09]

0.90

Retinal artery angle (degree)

– 0.005 [0.02]

0.75

0.0009 [0.02]

0.97

– 0.02 [0.03]

0.52

Average cpRNFL thickness (µm)

0.25 [0.02]

<0.0001*

0.31 [0.03]

< 0.0001*

– 0.06 [0.05]

0.21

Image quality score

0.08 [0.05]

0.07

0.04 [0.06]

0.45

0.03 [0.09]

0.70

  1. P values were derived from mixed-effects models with all listed variables. Asterisks indicate p values < 0.05 after Bonferroni correction.
  2. cpRNFL circumpapillary retinal nerve fiber layer, GCIPL ganglion cell inner plexiform layer, Coeff. Coefficients, SE standard errors, FDD fovea-disc distance, MD mean deviation, FDA fovea-disc angle.
  3. Significant values are in bold.