Table 2 Relationship between maternal polygenic risk scores and preeclampsia onset in the maternal cohorts by logistic regression analysis.

From: Preeclampsia prediction with maternal and paternal polygenic risk scores: the TMM BirThree Cohort Study

 

Internal validation cohort

External validation cohort

Meta-analysis

 

OR (95% CI)

P-value

OR (95% CI)

P-value

OR (95% CI)

P-value

P for heterogeneity

PRS for SBP

       

Continuous

1.01 (0.91 to 1.13)

0.794

1.33 (1.17 to 1.50)

< 0.001

1.14 (1.05 to 1.24)

0.002

0.001

Tertile 1

Reference

 

Reference

 

Reference

  

Tertile 2

1.09 (0.83 to 1.44)

0.532

1.02 (0.76 to 1.39)

0.874

1.06 (0.86 to 1.30)

0.570

0.761

Tertile 3

0.96 (0.73 to 1.26)

0.768

1.61 (1.21 to 2.16)

0.001

1.22 (1.00 to 1.49)

0.046

0.010

PRS for DBP

       

Continuous

1.08 (0.96 to 1.21)

0.186

1.39 (1.22 to 1.58)

< 0.001

1.20 (1.11 to 1.31)

< 0.001

0.003

Tertile 1

Reference

 

Reference

 

Reference

  

Tertile 2

0.80 (0.59 to 1.08)

0.150

1.33 (0.98 to 1.79)

0.063

1.03 (0.84 to 1.28)

0.768

0.020

Tertile 3

1.05 (0.80 to 1.37)

0.748

2.18 (1.62 to 2.94)

< 0.001

1.46 (1.19 to 1.78)

< 0.001

0.000

PRS for PE

       

Continuous

1.01 (0.91 to 1.13)

0.817

1.21 (1.07 to 1.37)

0.002

1.10 (1.01 to 1.19)

0.026

0.030

Tertile 1

Reference

 

Reference

 

Reference

  

Tertile 2

1.05 (0.81 to 1.35)

0.705

1.34 (0.96 to 1.88)

0.085

1.15 (0.94 to 1.41)

0.179

0.252

Tertile 3

1.04 (0.79 to 1.36)

0.792

1.49 (1.08 to 2.05)

0.014

1.20 (0.98 to 1.48)

0.076

0.087

  1. PRS: polygenic risk score; PE: preeclampsia; OR: odds ratio; CI: confidence interval; SBP: systolic blood pressure; and DBP: diastolic blood pressure. Two models were developed, one with PRS as a continuous value and the other as tertile values. All results were adjusted for maternal age at conception and four genetic principal components. P for heterogeneity was calculated by the Cochran Q test.
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