Fig. 2
(A) Representative examples of U87MG and RN1-luc xenograft anatomy in T1 and T2 weighted scans, including post-Gadovist (0.1 mmol/kg). (B) Brain histology of U87MG and RN1-luc patient-derived orthotopic xenografts, stained with Perls’ Prussian blue and counterstained with 0.1% safranin O. RN1-luc shows a distinctly diffuse phenotype whereby it has spread laterally across hemispheres, whereas U87MG shows a demarcated non-diffuse phenotype. Scale bars = 1 mm and 400 microns respectively. Images were acquired using a 20x objective. Tumour affected areas are outlined in dashed green in accordance with T2 weighted hyperintensity and histological staining.
