Fig. 3

T1- and T2*-weighted MR images of (A) U87MG and (B) RN1-luc patient-derived xenografts pre- and two minutes post-injection of either 0.1 mmol/kg Gadovist or 10 mg/kg PEGSPIONs. (C) Quantification of change in pre- to post- injection from representative regions of interest (ROIs) in T1 and T2* weighted images. ROIs were drawn around the brighter (T1w) or darker (T2*w, e.g. yellow arrow) appearing tumour regions and quantified relative to the same ROIs in the pre-injection images, and compared to control hemisphere non-tumour area, giving mean ± SEM post/pre injection values (n = 3). One U87MG mouse (blue data point) was imaged at 3 T rather than 7 T. * denotes p < 0.05, ** p < 0.01 and *** p < 0.001, as measured by two-way ANOVA with Šídák’s multiple comparisons test.