Fig. 5 | Scientific Reports

Fig. 5

From: Enhanced detection of glioblastoma vasculature with superparamagnetic iron oxide nanoparticles and MRI

Fig. 5

(A) Biodistribution of the PEG-SPIONs (representative image, n = 3), as shown by 7T MR T1-weighted spin echo images in NOD-SCID mice. From left to right, top to bottom, lung (Lu), stomach (St), liver (Li), spleen (Sp), kidney (Ki), muscles (Mu) and bladder (Bl) are encircled in yellow. Displayed window width and window level are equal for all images. (B) Quantification of unscaled reconstructed k-space of 3 T T2*-weighted gradient recalled echo acquisitions in C57BL/6 mice over longer time points. Graph represents mean + SEM grey values (arbitrary units) from oval-shaped regions of interest in T2* weighted FLASH 3 T images (n = 2). (C) Representative histology images of 10 micron sections stained with Perls’ Prussian blue and 0.1% safranin O. Iron oxide is shown by blue colour, notably in the liver and spleen, and to some extent in the kidney at 1 h. Scale bar = 100 microns.

Back to article page