Fig. 5

ERK inhibitor PD98059 reversed the proliferation, migration and invasion effects of AJUBA plasmid in lung cancer cells. (A) The growth curves of H1299 and A549 cells transfected with AJUBA plasmid and/or PD98059. Two-tailed Student’s t-test was used to analyze the differences between the two groups. ^**P < 0.01, ^***P < 0.001. (B) The colony formation capacity of H1299 and A549 cells transfected with AJUBA plasmid and/or PD98059. Two-tailed Student’s t-test was used to analyze the differences between the two groups. ^*P < 0.05; ^**P < 0.01. (C) The migration of H1299 and A549 cells transfected with AJUBA plasmid and/or PD98059 (100X). Two-tailed Student’s t-test was used to analyze the differences between the two groups. ^*P < 0.05, ^***P < 0.001. (D) The invasion of H1299 and A549 cells transfected with AJUBA plasmid and/or PD98059 (200X). Two-tailed Student’s t-test was used to analyze the differences the between the two groups. ^**P < 0.01, ^***P < 0 001.