Fig. 1

Effects of APOE4 in Alzheimer’s Disease. The presence of the APOE4 isoform promotes the formation of β-amyloid, which in turn increases the formation of senile plaques and the aggregation of Tau protein. This leads to heightened neuroinflammation, resulting in clinical consequences such as neuronal loss and cognitive decline. Abbreviation: APOE: Apolipoprotein E;