Table 2 Formulas for insulin sensitivity indices calculation.

From: Exploring the genetic intersection between obesity-associated genetic variants and insulin sensitivity indices

IS Index

Formula (units)

Reference

Fasting indices

 QUICKI

1/ (log I0 (µU/L) + log G0 (mg/dl))

Katz et al.36

 Inv-HOMA-IR

-1 × (I0 (µU/L) × G0 (mmol)) / 22.5 

Matthews et al.37

OGTT0,120 indcies

 

 StumvollModi

0.156 − 0.0000459× I120 (pmol/L) − 0.000321× I0 (pmol/L) − 0.00541× G120 (mmol/L)

Stumvoll et al.38

 GuttIndex

75,000 + (G0 (mg/dl) - G120 (mg/dl)) × 0.19 × BW (kg) / (120 × MPG (mg/dl) × log(MSI (µU/L))

Gutt et al.39

OGTT0,30,120 indices

 Matsuda

10000 / (√ (G0 (mg/dl)) × (I0 ((µU/L)) × (mean G(mg/dl)) × (mean I((µU/L) ))

Matsuda et al.40

 BIGTTSI

exp (4.90 − (0.00402 × I0 (pmol/L)) − (0.000556 × I30 (pmol/L)) − (0.00127 × I120 (pmol/L)) − (0.152 × G0 (mmol/L)) − (0.00871 × G30 (mmol/L)) − (0.0373 × G120 (mmol/L)) − (0.145 × sex (male/female)) − (0.0376 × BMI (kg/m2)))

Hansen et al.41

  1. HOMA IR; Homeostatic model assessment of insulin resistance, Matsuda; Matsuda calculated by weighted mean based on the trapezoidal formula over OGTT time points (0,30,120 min glucose and insulin values), QUICKI; Quantitative insulin sensitivity check index, StumvollModi; Modified Stumvoll, BIGTT SI.