Fig. 5

Functional mechanisms of glioma ecotypes. (A,C) Kaplan-Meier plots showing differences in overall survival between patients with ecosystem E2 or E4 and those with other ecosystems in the cohort. (B,D) Interaction frequency and strength between different cell states within ecosystem E2 or E4. (E,F) Overview of outgoing and incoming signaling pathways in ecosystem E2 or E4. (G) Heatmap showing interactions of the COLLAGEN signaling pathway across different cell states in ecosystem E2. (H) Heatmap showing interactions of the SPP1 signaling pathway across different cell states in ecosystem E4.