Fig. 8

Interpretation of key features of the microbiome in a multi-layer network. (A) Multi-layer network of Microbe-Metabolite-mRNA/Protein interactions constructed using the top 20 important features from the microbiome and transcriptome. (B) Results of KEGG enrichment analysis for metabolites. (C) Results of KEGG enrichment analysis for mRNA/Protein. The threshold for enrichment analysis was set at adjust pvalue < 0.05.