Table 11 PD parameters of neopterin.

From: Investigation into the pharmacodynamics and pharmacokinetics of recombinant human interferon alfa-2b vaginal suppository following process optimization in chinese rhesus macaque

Parameter

Arithmetic mean ± SD(%CV)

Sample R (N = 12)

Sample S (N = 12)

Tmax1 (h)

24(2,48)

24(24,36)

PDmax (ng/ml)

14.77 ± 3.81

14.51 ± 4.33

AUEC0 − t (ng∙h/ml)

966.14 ± 319.16

1011.72 ± 350.04

λz (h− 1)

0.01 ± 0.00

0.01 ± 0.00

t1/2 (h)

61.28 ± 27.95

54.93 ± 20.90

Vz_F_obs (IU/ng)

123.71 ± 39.02

113.33 ± 29.44

Cl_F_obs (IU/(h∙ng))

1.56 ± 0.75

1.60 ± 0.70

AUEC_%Extrap (%)

28.31 ± 13.99

23.14 ± 10.61

  1. Notes: 1 Tmax is represented by the median (minimum, maximum), and other data are presented in the form of arithmetic mean ± SD (% CV) based on statistical tables.
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