Table 12 The results of PDmax, AUEC0 − t bidirectional unilateral t-test, and [1–2α] confidence interval method for neopterin (BES, N = 12).

From: Investigation into the pharmacodynamics and pharmacokinetics of recombinant human interferon alfa-2b vaginal suppository following process optimization in chinese rhesus macaque

Parameter

t-value

P-value

Geometric mean and ratio (N = 12)

Individual variability %CV of subjects

90% CI

Compared to the lower limit tL

Compared to the high limit tH

Compared to the lower limit PL

Compared to the high limit PH

Sample R

Sample S

(S/R) %

PDmax (ng/ml)

6.63

-8.14

0.0000

0.0000

14.27

13.95

97.75

7.41

92.53%~103.25%

AUEC0 − t (ng∙h/ml)

6.09

-3.70

0.0001

0.0020

909.72

960.56

105.59

11.20

97.22%~114.68%