Fig. 3
From: Role of peripheral cytokines and orbitofrontal cortex subregion structure in schizophrenia agitation
Correlation analysis between cytokines and OFC subregion structure in high and low agitation schizophrenia patients. (A) Correlation analysis of indicators of cytokines with OFC subregion volume (adjusted for illness duration and ICV) and OFC subregion cortical thickness (adjusted for illness duration) in patients with low agitation schizophrenia. The numbers shown in the volcano plots are correlation coefficients. The results showed that there was a negative correlation between zIL-6 levels and right mOFC volume using illness duration and ICV as covariates (r = −0.299, P = 0.049), and a positive correlation between zIL-8 levels and the cortical thickness of the left mOFC using illness duration as covariate (r = 0.320, P = 0.032) in the low agitation group. (B) Correlation analysis of indicators of cytokines with OFC subregion volume (adjusted for illness duration and ICV) and OFC subregion cortical thickness (adjusted for illness duration) in patients with high agitation schizophrenia. The numbers shown in the volcano plots are correlation coefficients. The results showed that there was a negative correlation between zIL-17 levels and left lOFC volume (r = −0.428, P = 0.026), a negative correlation between zIFN-γ levels and left mOFC volume using illness duration and ICV as covariates (r = −0.424, P = 0.028), and a positive correlation between zIL-4 levels and left mOFC cortical thickness using illness duration as covariate (r = 0.424, P = 0.025) in the high agitation group. Abbreviations: lOFC, the lateral orbitofrontal cortex; mOFC, the medial orbitofrontal cortex, ICV, intracranial volume. *P < 0.05.
