Fig. 3

HFD and CRS could induce learning and memory decline in mice. (A) Mean escape latency was determined daily in the IT and the RT stages. (B) Mean swimming speed in both the IT and RT stages. (C) Representative track images of SET (a single 60s probe trial was performed without the platform on day 6). (D) Number of platform area crossings in the SET stage. (E) Quadrant occupancy in the SET stage. (F) Representative track images of RET (a single 60s probe trial was performed without the platform on day 9). (G) Number of platform area crossings in the RET stage. (H) Quadrant occupancy in the RET stage. Data were expressed as mean ± SEM (n = 8), ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 vs. control group; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 vs. CRS group; ^$p < 0.05, ^$$p < 0.01, ^$$$p < 0.001 vs. HFD group.