Fig. 9

Reversal of anxiety and depression-like behaviors and learning and memory deficits by activating the Wnt/β-catenin signaling pathway. (A) Total fluid intake test (FIT) for SPT. (B) The percentage of sucrose consumption in the SPT. (C) Immobility time was determined in the FST. (D) Immobility time was determined in the FST. (E)The time in the center zone in the OFT. (F) Mean escape latency was determined daily in the IT and the RT stages. (G) Number of platform area crossings in the SET stage. (H) Quadrant occupancy in the SET stage. (I) Number of platform area crossings in the RET stage. (J) Quadrant occupancy in the RET stage. Data were expressed as mean ± SEM (n = 8), ^*p < 0.05, ^**p < 0.01, ^***p < 0.001 vs. control group; ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 vs. CON + SKL2001 group. ^$p < 0.05, ^$$p < 0.01, ^$$$p < 0.001 vs. HFD + CRS + vehicle group.