Table 9 Genetic variants associated to prolonged clinical and endoscopy remission.
Genetic variant | Prolonged* Clinical and Endoscopy Remission N | Univariate analysis | Multivariate analysis corrected by age, sex, smoking, and use of anti-TNF | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Genotype | No | Yes | OR | CI | P value | P value | OR | CI | P value | P value | ||
rs6871626 | 0 = CC | 114(93%) | 8(7%) | 122 | Ref | Ref | Ref | 0.03 | Ref | Ref | 0.0001 | 0.03 |
1 = AC | 124(89%) | 16(11%) | 140 | 1.83 | 0.77–4.68 | 0.17 | 1.81 | 0.76–4.68 | 0.19 | |||
2 = AA | 22(75%) | 7(24%) | 29 | 4.43 | 1.45–13.94 | 0.07 | 5.86 | 1.80-19.08 | 0.002 | |||
rs11168249 | 0 = TT | 137(94%) | 9(6%) | 146 | Ref | Ref | Ref | 0.03 | Ref | Ref | 0.002 | 0.03 |
1 = CT | 101(84%) | 19(16%) | 120 | 2.86 | 1.27–6.89 | 0.01 | 3.09 | 1.36–7.53 | 0.08 | |||
2 = CC | 22(88%) | 3(22%) | 25 | 2.07 | 0.43–7.56 | 0.30 | 2.01 | 0.41–7.55 | 0.32 | |||
rs7134599 | 0 = GG | 144(94%) | 10(6%) | 154 | Ref | Ref | Ref | 0.03 | Ref | Ref | 0.0002 | 0.03 |
1 = AG | 98(86%) | 16(14) | 114 | 2.35 | 1.03–5.56 | 0.04 | 2.43 | 1.06–5.82 | 0.04 | |||
2 = AA | 18(88%) | 5(22%) | 23 | 4.00 | 1.14–12.66 | 0.02 | 3.88 | 1.09–12.44 | 0.02 | |||
rs11150589 | 0 = CC | 124(91%) | 12(9%) | 136 | Ref | Ref | Ref | 0.02 | Ref | Ref | 0.0007 | 0.02 |
1 = TC | 115(91%) | 11(9%) | 126 | 0.98 | 0.41–2.34 | 0.98 | 0.96 | 0.40–2.30 | 0.93 | |||
2 = TT | 21(72%) | 8(28%) | 29 | 3.93 | 1.39–10.72 | 0.007 | 4.02 | 1.40-11.23 | 0.007 | |||
rs2651244 | 0 = GG | 137(93%) | 10(7%) | 147 | Ref | Ref | Ref | 0.02 | Ref | Ref | 0.003 | 0.02 |
1 = AG | 106(88%) | 15(12%) | 121 | 1.93 | 0.84–4.62 | 0.12 | 1.87 | 0.80–4.50 | 0.15 | |||
2 = AA | 17(74%) | 6(26%) | 23 | 4.83 | 1.48–14.80 | 0.006 | 5.12 | 1.55-16.00 | 0.005 | |||
