Table 1 α-Glucosidase inhibitory activity of compounds 14a-n.

From: 1-Phenyl-β-carboline-3-carboxamide-1,2,3-triazole-N-phenylacetamide hybrids as new α-glucosidase inhibitors

Compound

R1

R2

IC50 (µM)

14a

H

H

78.4 ± 0.4

14b

H

2-CH3

64.0 ± 0.8

14c

H

2-CH3-4-NO2

660.2 ± 2.1

14d

H

3-Cl

261.8 ± 1.5

14e

H

2-NO2-4-OCH3

285.7 ± 2.2

14f

OCH3

H

661.4 ± 0.8

14 g

OCH3

2-CH3

508.8 ± 1.9

14 h

OCH3

2-F

516.8 ± 1.1

14i

OCH3

3-Cl

196.2 ± 0.6

14j

Cl

H

149.8 ± 1.7

14k

Cl

2-CH3

609.7 ± 1.0

14 L

Cl

2-CH3-4-NO2

203.2 ± 1.3

14 m

Cl

2-F

162.0 ± 1.7

14n

Cl

3-Cl

222.2 ± 2.3

Acarbose

-

-

750.0 ± 1.4

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