Table 3 Druglikeness study and ADMET prediction of acarbose and the selected compounds 14b and 14a.

From: 1-Phenyl-β-carboline-3-carboxamide-1,2,3-triazole-N-phenylacetamide hybrids as new α-glucosidase inhibitors

Druglikeness/ADME/T a

Compound

Acarbose

14b

14a

Rule of Five

Violated

Suitable

Suitable

Caco2

9.44448

4.49089

3.81263

HIA

0.000000

93.813980

93.662826

BBB

0.0271005

0.554051

0.391001

Skin permeability

-5.17615

-3.46758

-3.54089

Ames test

Mutagen

Non-mutagen

Non-mutagen

Carcino mouse

Positive

Negative

Negative

Carcino rat

Negative

Negative

Negative

  1. aThe recommended ranges for Caco2: <25 poor, > 500 great, HIA: >80% is high < 25% is poor, BBB = − 3.0–1.2, and Skin_Permeability = − 8.0 – − 1.0.
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