Table 3 Baseline and post-intervention values of iron metabolism, inflammatory, and neurotrophic markers following 14 days of IPC or SHAM intervention.

From: Ischemic preconditioning modulates iron metabolism, acute inflammatory and neurotrophic responses to anaerobic exercise in untrained individuals: a randomized controlled trial

Variable	Unit	IPC group (n = 15)
		Before		After		Before			After
		Mean ± SD	95% CI	Mean ± SD	95% CI	Mean ± SD	95% CI	Mean ± SD		95% CI
Erythroferrone	pg/mL	568.62 ± 150.09†	492.66–644.58	622.87 ± 143.36	550.33–695.42	535.08 ± 75.20	494.20–575.96	542.02 ± 78.61		499.29–584.75
Erythropoietin	mU/mL	9.93 ± 1.25	9.40–10.46	11.08 ± 1.01	10.57–11.60	10.59 ± 1.58	9.73–11.44	11.16 ± 1.77		10.20–12.12
Ferritin	ng/ml	110.89 ± 15.33†#	103.13–118.64	120.85 ± 20.33	110.55–131.13	141.95 ± 31.81	124.66–159.24	134.66 ± 31.60		117.48–151.84
Hepcidin	ng/mL	84.25 ± 32.55†	67.78–100.72	94.45 ± 31.56	78.48–110.42	71.49 ± 43.01	48.11–94.87	73.48 ± 42.68		50.27–96.68
Iron	umol/l	19.71 ± 6.49	16.42–22.99	20.23 ± 6.09*	17.14–23.31	22.14 ± 10.93*	16.20–28.08	29.62 ± 7.18		25.72–33.52
FSTL-1	ng/mL	17.29 ± 1.83	16.36–18.22	15.76 ± 3.23	14.12–17.39	16.89 ± 0.98	16.36–17.43	15.95 ± 2.42		14.63–17.27
GDF-15	pg/mL	0.37 ± 0.07	0.33–0.41	0.35 ± 0.09	0.30–0.40	0.33 ± 0.05	0.31–0.37	0.331 ± 0.06		0.30–0.37
IL-10	pg/mL	10.18 ± 0.94		9.56 ± 1.04		10.09 ± 0.76		9.71 ± 1.18
IL-15	pg/mL	16.91 ± 6.35	13.70–20.12	16.95 ± 3.85	15.01–18.90	19.45 ± 2.84	17.90–20.99	17.68 ± 5.40		14.74–20.61
IL-6	pg/mL	5.83 ± 0.61	5.52–6.14	5.13 ± 0.61	4.82–5.43	5.37 ± 0.74	4.96–5.77	5.13 ± 0.61		4.80–5.46
LIF	pg/mL	39.20 ± 9.81	34.23–44.16	30.58 ± 8.45	26.30–34.86	37.04 ± 6.70	33.40–40.68	36.07 ± 7.66		31.91–40.24
BDNF	pg/mL	16.69 ± 3.39	14.97–18.41	16.47 ± 2.95	14.98–17.97	15.43 ± 4.48	13.00–17.88	15.62 ± 4.18		13.35–17.90
IGF	pg/mL	12.38 ± 4.64	10.03–14.74	12.41 ± 2.81	10.99–13.84	14.24 ± 2.08	13.07–14.95	12.94 ± 3.95		10.80–15.10
NGF	pg/mL	41.12 ± 5.07	38.56–43.69	41.99 ± 4.97	39.48–44.51	41.96 ± 4.89	39.31–44.63	41.61 ± 2.39		40.31–42.92
sAPP	pg/mL	25.52 ± 2.92	24.05–26.99	27.26 ± 3.54	25.48–29.07	24.44 ± 2.49	23.08–25.80	25.53 ± 2.03		24.43–26.64

IPC, ischemic preconditioning group; SHAM, s ham controlled group (control group); FSTL-1, follistatin-like 1; GDF-15, growth differentiation factor 15; IL-6, interleukin-6; IL-10, interleukin-10; IL-15, interleukin-15; LIF, leukemia inhibitory factor; BDNF, brain-derived neurotrophic factor; IGF-1, insulin-like growth factor-1; NGF, nerve growth factor; sAPPα, Amyloid Precursor Protein.
*significant differences vs. SHAM group after 14-days SHAM intervention (p < 0.01);

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Table 3 Baseline and post-intervention values of iron metabolism, inflammatory, and neurotrophic markers following 14 days of IPC or SHAM intervention.

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