Fig. 8: The Effects of RNF4/PDHA1 axis on in vivo growth and metastasis of CRC cells.
From: RNF4 mediated degradation of PDHA1 promotes colorectal cancer metabolism and metastasis
A Subcutaneous tumor dissection images of mice from each group on day 35; B Line graph showing the tumor volume growth from day 5 to day 35 in each group of mice; C Tumor weight statistics on day 35 in each group of mice; D Immunohistochemical staining detecting the positive expression of proliferation markers Ki67 and PCNA in subcutaneous tumor tissues of mice from each group (scale bar = 50 μm or 25 μm); E IVIS Lumina II imaging system measuring lung metastatic nodules in mice from each group; F Representative images of lung metastatic nodules in mice from each group, indicated by black arrows; G Representative images of liver metastatic nodules in mice from each group. n = 8, * indicates P < 0.05 compared to sh-NC group, # indicates P < 0.05 compared to sh-RNF4 group.
